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Synergy between the antinociceptive effects of morphine and NSAIDs
(2004)
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...
Isoniazid and verapamil modulatory activity and efflux pump gene expression in Mycobacterium tuberculosis
(Int Union Against Tuberculosis Lung Disease (i U A T L D), 2020-06-01)
INTRODUCTION: Resistance to first-line anti-tuberculosis drugs is a major concern in the treatment of the disease. New strategies, such as the use of efflux pump inhibitors (EPIs), are being investigated to improve the ...
Dual antibacterial drug-loaded nanoparticles synergistically improve treatment of Streptococcus mutans biofilms
(Elsevier B.V., 2020-10-01)
Dental caries (i.e., tooth decay), which is caused by biofilm formation on tooth surfaces, is the most prevalent oral disease worldwide. Unfortunately, many anti-biofilm drugs lack efficacy within the oral cavity due to ...
Alternative treatment of fungal infections: Synergy with non-antifungal agents
(Wiley Blackwell Publishing, Inc, 2021-03)
Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies ...
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Nature Publishing Group, 2019-06-17)
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven ...
Antinociceptive Synergism of Gabapentin and Nortriptyline in Mice with Partial Sciatic Nerve Ligation
(Karger, 2015)
Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an ...
Modelagem computacional de redes genéticas regulatórias
(Universidade Federal de Santa MariaBRFísicaUFSMPrograma de Pós-Graduação em Física, 2016-09-30)
In biology, regulatory networks are sets of macromolecules, mostly proteins and
RNAs that interact to execute task. The main players in regulatory networks are DNAbinding
proteins, also called transcription factors as they ...
Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis
(American Society for Microbiology, 2017)
Medicinal chemistry approaches to neglected diseases drug discovery
(Synergy PublishersKarachi, 2014-02)
The prevalence of a variety of neglected diseases is an increasing serious public health problem in developing countries, particularly in the poorest and most remote areas with very little or no access to medical care. The ...